Paracetamol: History, Structure and Dangers

Paracetamol: History, Structure and Dangers What is Paracetamol? Depending on where you live in the world, N-(4-hydroxyphenyl)ethanamide is known as Paracetamol or acetaminophen with the molecular formula of C8H9NO2. Paracetamol or acetaminophen belongs to a group of medicines which have analgesic (pain reliever) and antipyretic (fever reliever) properties. For these reasons it is used for reliving a person of mild to moderate pain including headache, joint pain and toothache. In Addition to controlling fever (high temperature) Paracetamol can also be used to relive symptoms of cold. History of Paracetamol The history and discovery of Paracetamol is fascinating as it was discovered by accident when a similar molecule acetanilide was put to use as an analgesic and antipyretic medicine in the late 1800s. At the approach of 20th century the discovery and synthesis of medicine was based on pure chance, as scientists randomly tested new compounds on test subjects (mainly humans, without any awareness of their possible side effects) to examine both their positive and negative effects. The discovery of Paracetamol can be linked with the discovery of acetanilide which was the first derivative of aniline (see figure 1.1) to be found to contain analgesic and antipyretic properties. Figure 1.1 shows the structure of the organic compound aniline Acetanilide was synthesised when the aniline gained a secondary amide group. This occurred when aniline was reacted with ethanoic anhydride, resulting in the production of C8H6NCOCH3 and CH3COOH (ethanoic acid). The equation for the reaction is as follows: C6H5NH2 + (CH3CO)2O → C6H5NHCOCH3 + CH3COOH Soon after the discovery acetanilide (see Figure 1.2) was produced to be used in therapy in 1886, and it remained in use for several years due to how cheap it was to mass produce. The painkilling properties of the synthetic organic compound acetanilide were impressive but it had to be abandoned due its high toxicity in moderate doses. For example, it was known to interfere with the function of the oxygen-carrying pigment haemoglobin which caused cyanosis in patients. Figure 1.2 shows the structure of the organic compound acetanilide As a result a new search began which lead to the discovery of a new derivative called N-4-(-Ethoxyphenyl)ethanamide(see figure 1.3). To their surprise the new derivative contained the same analgesic and antipyretic properties but was less toxic than acetanilide. The first synthesis was reported in 1878 by Harmon Northrop Morse (3). It wasn’t until 1886 that this new drug was marketed under the name phenacetin. It remains in use ever since but the usage has declined due its undesirable side effects on the liver. Although Phenacetin I still being used today in some parts of the country, it was banned in USA by the FDA in 1983 after research showed it had adverse side effects such as kidney damage. Figure 1.3 shows the structure of the organic compound Phenacetin Finally, in 1893 a German physician Joseph von Mering managed to improve phenacetin resulting in the production of Paracetamol. Unfortunately, Joseph Von Mering mistakenly thought that Paracetamol had similar adverse effects as acetanilide did and therefore ignored the discovery. It wasn’t until the 1940’s when this misunderstanding was removed after research showed that Paracetamol was the main metabolite of phenacetin (see figure 1.4) and potentially caused the desired side effects. Further studies showed that it was the other minor metabolite that caused the negative effects and that Paracetamol was responsible for the positive effects. This finally led to Paracetamol being put to use a synthetic medicine in 1953 and its being used ever since. Today Paracetamol is manufactured by a number of different pharmaceutical companies with different brand names. In the UK alone there are more than ninety over the counter medicines which contain Paracetamol. Paracetamol is sometimes combined with other medicines such as decongestants (provides relief for blocked nose). Figure 1.4 Shows Paracetamol as the major metabolite (99%) of Phenacetin (5) Mechanism of action For reducing temperature Paracetamol is believed to act on a region of the brain called the hypothalamus which is responsible for regulation of body temperature. Paracetamol reduces pain by directly interfering with chemicals in the body called prostaglandins. These prostaglandins act much like hormones (chemical messengers) but do not move to other sites, they remain in the cell in which they were synthesised in. Prostaglandin are thought to be involved in the dilation of blood vessels which cause pain. Paracetamol is recognised by the enzyme which is responsible for the biosynthesis of prostaglandins in the body. Paracetamol inhibits the biosynthesis of prostaglandins. Therefore, reduction in the number of prostaglandin reduce the awareness to pain in the body. Dangers of Paracetamol Paracetamol is a potent medicine which is easily available without any prescription, even small overdoses can be fatal, because it is metabolised into both toxic and non-toxic products in the liver. For this reason, Paracetamol is often used as suicide drug. Paracetamol overdose can cause liver failure because it is a hepatoxic, which means even in moderate doses it can cause damage to hepatocytes (liver cells). People who use Paracetamol as means of suicide die from liver damage and most of the poisoning is due to a metabolite of Paracetamol called quinone amine (see figure 1.5). Quinone amine is dangerously toxic and is eliminated from the body in the liver by a reaction with glutathione (a tripeptide). Insufficient levels of glutathione means the toxic quinone amine will not be eliminated and starts to build up. Eventually it will start to react with nucleic acids and cellular proteins in the liver causing permanent damage and eventually death. References CSID:5889, http://www.chemspider.com/Chemical-Structure.5889.html (accessed 19:47, Oct 31, 2014) CSID:880, http://www.chemspider.com/Chemical-Structure.880.html (accessed 20:47, Oct 31, 2014) H. N. Morse (1878). Ueber eine neue Darstellungsmethode der Acetylamidophenole. Berichte der deutschen chemischen Gesellschaft 11 (1): 232–233. doi:10.1002/cber.18780110151 CSID:4590, http://www.chemspider.com/Chemical-Structure.4590.html (accessed 16:21, Nov 1, 2014) Ellis, Frank. Paracetamol a curriculum recource . RSC, http://www.rsc.org/learn-chemistry/content/filerepository/CMP/00/000/047/Paracetamol_web.pdf. (accessed 21:1, Nov 1, 2014.]

Hotel Management Documentation

` USER MANUAL CONTENTS 1. Introduction 2. Getting Started 3. Main Menu 4. Master file Maintenance 5. Payroll Reports 6. Payroll data Backup and Restore INTRODUCTION Confide payroll system is a windows payroll software written in Microsoft Visual Basic (VB. NET). Although confide pay system is extremely powerful it is in no way difficult to use. The payroll software includes many new features that enable the user to do your work easier and faster. In this windows version, user will improve productivity with time saving windows feature.All command bars and drop menus are logically organised in systematic manner that will enable user to operate smoothly. Confide payroll is highly respected because of its high performance, user friendly and data integrity. We therefore strive for the best improvement to support customers in terms of quality. These notes, together with the practical you will do during the day, will ensure that learning to use the system is an informative and useful experi ence for you. GETTING STARTED After installation procedure a shortcut icon is created on the desktop to provide easy access to your program.Double click the shortcut icon to gain access to your Confide payroll system. When you see the log in main screen appears, you have to type in the correct information so that you can successfully enter into the system. 1) Enter your User name in the text box provided. Press Tab to move to the next box. 2) Enter your password. The password is case sensitive so ensure that your Caps lock key is on or off as required. MAIN MENU Once you have entered your password and selected the payroll required you will find yourself in the Opening menu.Features include: – 1) A drop down list of all the chief program options. Like the drop down lists in other Windows menus, if a folder has a + in the box beside it, when you click the + 2) A list of the options included in that folder will drop down, while the + changes to a – COMPANY SETUP Before at tempting to store any employees, you have to enter your company details. Go to MAIN MENU select FILE and then click on the NEW COMPANY tab the following window appears Enter all your company details and press the Save button on menubar. PAYROLL STANDARDSTo setup the payroll standards you go on the SETUP Menu, SELECT Payroll Standards then set your standard hours and days. PAYROLL CALENDAR Under the main menu select SETUP go to PAYROLL CALENDAR then in the textbox enter the 12 runs per year. Set your calendar from January to December. MASTERFILE MAINTAINACE The section enables the user to add, update, delete and view employees in the master file. Employee details such as Name, Date of Birth, ID Number, Medical aid scheme and number of dependents are stored in the Employee File. ENTERING A NEW EMPLOYEE 1.Select Employees from the Confide Navigation bar and double click ALL employees, click the new employee Button. 2. The employee data entry screen offers a series of tabs each correspo nding to a Page of information about the employee. . 3. Click on the tab with the details you need to enter and enter the details about the employee in the form presented – see example overleaf. PAYROLL RUN To run the payroll, go onto the Payroll menu select Payroll Run. The following form appears select the Process button. You will be asked to backup your data for payroll pre run .Specify your data backup name and SQL path and press OK. PAYROLL REPORTS PAYROLL SUMMARY To view the payroll summary select the + sign on the REPORTS icon on the payroll navigation bar types of reports are shown as shown on the screen below: Double click on the payroll summary icon and the payroll summary for the month is displayed. PAYSLIPS To view and print pay slips on the reports menu double click the pay slip icon and you will be asked to enter the date to be printed on the pay slip and also to select the number of pay slips you want to print and then press OK.The pay slips will be generated a utomatically. DATA BACKUP Backup – A backup is a compressed copy of your data at the moment when you make the backup. Work that you do after a backup is lost if the backup is restored, so that we recommend that a backup is done every 30mins when working on the payroll. Clicking on the payroll on the menu bar and select payroll data backup button will bring up a screen that allows you to back up your data as shown below:Specify your backup name, the path where you want to store your backup and select OK a message is shown for notification that your payroll data had been successful saved. RESTORE The option to restore is found under payroll on the main menu, as shown in Fig 2g below. Selecting this option brings up the Data Restore screen 1) Select the path on which source database is stored 2) Select the SQL Server Data Path 3) Select one of the two buttons shown and your data will be successfully restored.

Biological, Psychological, And Social Factors - 1505 Words

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